Acetyl hexapeptide-8

Classification

Neurotransmitter-affecting peptide (cosmetic topical)

Approval status

Cosmetic

Research status

Investigational / reference listing.

Molecular formula

Insufficient reliable evidence identified.

Molecular weight

Insufficient reliable evidence identified.

Sequence

Acetylated hexapeptide mimicking the N-terminal SNAP-25 fragment (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2).

Primary biological target

Insufficient reliable evidence identified.

Half-life

Insufficient reliable evidence identified.

Routes investigated

Insufficient reliable evidence identified.

Human evidence level

C — Limited or early human evidence

A topical cosmetic peptide explored for the appearance of expression lines. It is not botulinum toxin and is not an approved wrinkle medicine.

In vitro, related sequences can interfere with SNARE-complex assembly. Whether topical leave-on products reproduce that pharmacology in living facial muscle is uncertain; cosmetic outcomes, if any, are modest compared with prescription neuromodulators.

Applied to intact skin as a cosmetic. It does not replace prescription anti-wrinkle injections.

• Appearance of periorbital expression lines (cosmetic)

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Overall human evidence grade: C · Limited or early human evidence

Small cosmetic studies exist; effect sizes are typically modest and formulations vary widely.

Animal, cell and in-vitro findings are listed separately from human effects.

SNARE-related in-vitro work underpins marketing narratives.

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

Irritation possible; not for injection.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Broken skin; hypersensitivity to ingredients.

Cosmetic ingredient, not a toxin medicine.

Cosmetic use only. Botulinum toxin type A products are separate prescription medicines and are not sold here.

1. [1] Acetyl hexapeptide-8 mechanism overview

   Acetyl hexapeptide-8 mechanism overview