Acetyl octapeptide-3

Classification

Cosmetic SNAP-25 analogue (topical)

Approval status

Cosmetic

Research status

Investigational / reference listing.

Molecular formula

Insufficient reliable evidence identified.

Molecular weight

Insufficient reliable evidence identified.

Sequence

Acetylated octapeptide related to SNAP-25 fragments; longer analogue of acetyl hexapeptide-8.

Primary biological target

Insufficient reliable evidence identified.

Half-life

Insufficient reliable evidence identified.

Routes investigated

Insufficient reliable evidence identified.

Human evidence level

C — Limited or early human evidence

A topical cosmetic peptide for the look of expression lines. Supplier ‘Snap-8 vials’ for injection are not the same as a leave-on cosmetic and are not sold here.

Proposed SNARE-related topical mechanism; clinical effect sizes are modest versus prescription neuromodulators.

Intended for intact skin as a cosmetic.

• Appearance of expression lines

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Overall human evidence grade: C · Limited or early human evidence

Evidence is mainly cosmetic or ingredient-supplier studies, not pharmaceutical Phase 3 programmes.

Animal, cell and in-vitro findings are listed separately from human effects.

In-vitro and small dermal models are commonly cited by manufacturers.

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

Topical irritation is possible. Do not inject cosmetic ingredients.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Hypersensitivity to the ingredient or formulation. Not for broken skin unless a clinician directs.

Cosmetic ingredient / branded cosmetic active. Not an approved systemic medicine.

Permitted in cosmetics when formulated and advertised within cosmetic rules. Cellular Sequence does not sell research-chemical injectables of these actives.

1. [1] Encyclopaedia note

   Encyclopaedia note