ACTH (1–39)

Classification

Pituitary tropic peptide hormone

Approval status

Approved medicine

Research status

Labelled indications are defined in product information.

Molecular formula

Insufficient reliable evidence identified.

Molecular weight

Insufficient reliable evidence identified.

Sequence

39-residue ACTH; diagnostic analogues (e.g. tetracosactide) are licensed separately.

Primary biological target

Insufficient reliable evidence identified.

Half-life

Insufficient reliable evidence identified.

Routes investigated

Insufficient reliable evidence identified.

Human evidence level

A — Approved clinical use / strong human evidence

A hormone that drives adrenal cortisol. Research ‘ACTH 1-39’ vials are not Synacthen tests.

MC2 receptor agonism on the adrenal cortex.

Acute steroidogenesis; chronic excess is Cushing-like.

• Adrenal diagnostic testing
• Selected inflammatory protocols historically

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Overall human evidence grade: A · Approved clinical use / strong human evidence

Licensed corticotropin analogues exist; catalogue ACTH is not equivalent.

Animal, cell and in-vitro findings are listed separately from human effects.

Classic pituitary–adrenal axis.

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

Hypertension, hyperglycaemia, infection risk, mood change if bioactive.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Systemic steroid-axis drugs require specialist oversight.

Approved as specific diagnostic/therapeutic presentations.

Cellular Sequence does not sell this as a vial, tablet, oil, or injectable. Educational encyclopaedia listing only.

1. [1] Encyclopaedia note

   Encyclopaedia note