FOXO4-DRI

Research / investigational listing only. This compound is not available for consumer purchase from Cellular Sequence and must not be confused with shop products.

Research / investigational compoundThis compound does not have an established approved therapeutic dosing schedule. Doses below describe those reported in published scientific research and should not be interpreted as a treatment recommendation.

At-a-glance profile

Classification: D-retro-inverso peptide (senolytic research)
Approval status: Research only · Not approved for human use
Research status: Investigational / reference listing.
Molecular formula: Insufficient reliable evidence identified.
Molecular weight: Insufficient reliable evidence identified.
Sequence: Synthetic D-peptide designed to perturb FOXO4–p53 interaction in research.
Primary biological target: Insufficient reliable evidence identified.
Half-life: Insufficient reliable evidence identified.
Routes investigated: Insufficient reliable evidence identified.
Human evidence level: D — Primarily animal / preclinical evidence

What is it?

Experimental senolytic-concept peptide. Not an approved longevity drug. Not sold.

Mechanism of action

Proposed disruption of FOXO4-p53 in senescent-cell models.

Not a human-registered senolytic.

What is it being studied for?

Cellular senescence models

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Evidence level

Overall human evidence grade: D · Primarily animal / preclinical evidence

Human research

Inadequate.

Preclinical research

Animal, cell and in-vitro findings are listed separately from human effects.

High-profile but limited-replication space — treat cautiously.

Doses reported in published research

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Pharmacokinetics

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

Safety

Unknown; theoretically significant.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Not for human use.

Regulatory status

Not approved.

Educational warning.

Citations

[1] Encyclopaedia note
Encyclopaedia note

For educational and research reference only. This page summarises published scientific literature and does not constitute medical advice, prescribing information or a recommendation to use an investigational compound. Research doses shown describe doses reported in published studies and are not personalised dosing instructions.

Last reviewed 2026-09-13. Research areas: Healthy Ageing · Compare peptides