Melatonin

Classification

Indoleamine hormone (not a peptide)

Approval status

Approved medicine

Research status

Labelled indications are defined in product information.

Molecular formula

Insufficient reliable evidence identified.

Molecular weight

Insufficient reliable evidence identified.

Sequence

Small tryptophan metabolite; listed on peptide price sheets anyway.

Primary biological target

Insufficient reliable evidence identified.

Half-life

Insufficient reliable evidence identified.

Routes investigated

Insufficient reliable evidence identified.

Human evidence level

A — Approved clinical use / strong human evidence

A circadian hormone available as licensed or listed oral products in some markets. Injectable ‘melatonin 10 mg vials’ are not those products and are not sold here.

MT1/MT2 receptor signalling and circadian phase-shifting.

Sleepiness, prolactin and temperature effects.

• Jet lag / insomnia in specific licensed presentations

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Overall human evidence grade: A · Approved clinical use / strong human evidence

Oral melatonin has a mixed evidence base; injectable research stock is unjustified.

Animal, cell and in-vitro findings are listed separately from human effects.

Pineal hormone biology.

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

Next-day sedation, vivid dreams; injection adds infection risk.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Follow labelled oral products; do not inject research melatonin.

Oral products may be listed/registered; injectable research melatonin is unapproved.

Cellular Sequence does not sell this as a vial, tablet, oil, or injectable. Educational encyclopaedia listing only.

1. [1] Encyclopaedia note

   Encyclopaedia note