PDRN (polydeoxyribonucleotide)

Classification

DNA fragment mixture (not a peptide)

Approval status

Cosmetic

Research status

Investigational / reference listing.

Molecular formula

Insufficient reliable evidence identified.

Molecular weight

Insufficient reliable evidence identified.

Sequence

Depolymerised DNA used in some skin procedures and cosmetics.

Primary biological target

Insufficient reliable evidence identified.

Half-life

Insufficient reliable evidence identified.

Routes investigated

Insufficient reliable evidence identified.

Human evidence level

C — Limited or early human evidence

A polynucleotide skin ingredient/procedure class, often listed next to peptides. Not sold as an injectable kit here.

Proposed A2A receptor / wound-healing narratives in aesthetic literature.

Device/clinic context in some countries; mail-order vials are not that setting.

• Aesthetic dermatology literature of mixed quality

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Overall human evidence grade: C · Limited or early human evidence

Mostly aesthetic series, not TGA-standard drug approval for anonymous vials.

Animal, cell and in-vitro findings are listed separately from human effects.

Nucleic-acid fragment biology.

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

Injection-site reactions.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Not a home injectable.

Device/cosmetic/medicine status varies; research vials are not sold.

Cellular Sequence does not sell this as a vial, tablet, oil, or injectable. Educational encyclopaedia listing only.

1. [1] Encyclopaedia note

   Encyclopaedia note