Teriparatide

Classification

Parathyroid hormone fragment (anabolic bone medicine)

Approval status

Approved medicine

Research status

Labelled indications are defined in product information.

Molecular formula

Insufficient reliable evidence identified.

Molecular weight

Insufficient reliable evidence identified.

Sequence

Recombinant PTH (1–34).

Primary biological target

Insufficient reliable evidence identified.

Half-life

Insufficient reliable evidence identified.

Routes investigated

Insufficient reliable evidence identified.

Human evidence level

A — Approved clinical use / strong human evidence

A prescription anabolic treatment for selected osteoporosis patients. Grey-market ‘teriparatide / triparatide’ vials are not Forteo.

Intermittent PTH-receptor signalling can increase bone formation when used as labelled.

Bone turnover and calcium handling; specialist monitoring is required.

• Severe osteoporosis in labelled populations

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Overall human evidence grade: A · Approved clinical use / strong human evidence

Registration trials exist for licensed teriparatide.

Animal, cell and in-vitro findings are listed separately from human effects.

PTH fragment biology is established.

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

See the Australian Product Information for the licensed brand. Grey-market vials are not equivalent.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Follow labelled contraindications. Unlicensed research vials are not a substitute.

Approved prescription medicine as specific brands; duration limits apply.

Cellular Sequence does not sell this as a vial, tablet, oil, or injectable. Educational encyclopaedia listing only.

1. [1] Encyclopaedia note

   Encyclopaedia note