Triptorelin

Classification

Long-acting GnRH agonist

Approval status

Approved medicine

Research status

Labelled indications are defined in product information.

Molecular formula

Insufficient reliable evidence identified.

Molecular weight

Insufficient reliable evidence identified.

Sequence

Modified GnRH decapeptide used as depot medicines in oncology and gynaecology.

Primary biological target

Insufficient reliable evidence identified.

Half-life

Insufficient reliable evidence identified.

Routes investigated

Insufficient reliable evidence identified.

Human evidence level

A — Approved clinical use / strong human evidence

A prescription hormone-suppression medicine in licensed depots. Tiny research vials labelled triptorelin are not those products.

Initial gonadotropin flare then pituitary desensitisation and sex-steroid suppression.

Profound HPG-axis shutdown if bioactive — inappropriate outside specialist care.

• Hormone-sensitive cancers
• Selected gynaecological indications

Investigational findings are not proven clinical benefits unless an authority has labelled that indication.

Overall human evidence grade: A · Approved clinical use / strong human evidence

Extensive for licensed depots, none for anonymous 2 mg research kits.

Animal, cell and in-vitro findings are listed separately from human effects.

GnRH agonist class is well described.

This section does not provide personalised medical dosing. Values are those reported in papers or protocols. Animal mg/kg doses are not converted to human doses.

Doses reported in human studies

Insufficient reliable evidence identified.

Preclinical / animal study dosing

Insufficient reliable evidence identified.

Reliable human pharmacokinetic data were not identified for this encyclopaedia entry, or are limited to product information for approved presentations.

See the Australian Product Information for the licensed brand. Grey-market vials are not equivalent.

Unknowns. Absence of a published harm signal is not evidence of safety.

Contraindications. Follow labelled contraindications. Unlicensed research vials are not a substitute.

Approved as specific depot medicines.

Cellular Sequence does not sell this as a vial, tablet, oil, or injectable. Educational encyclopaedia listing only.

1. [1] Encyclopaedia note

   Encyclopaedia note